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產(chǎn)品名稱

AIM 100

產(chǎn)品貨號(hào)

Axon 2031 CAS [873305-35-2] MF C23H21N3O2MW 371.43 Purity: 99% Optical purity: 98.1% e.e. Soluble in DMSO Description Specific inhibitor of Ack1 tyrosine kinase (also known as TNK2); AIM-100 inhibits Ack1 activity and also suppresses androgen receptor (AR) Tyr(267) phosphorylation and its recruitment to the ATM enhancer (Ack1/AR/ATM signaling) References Certificates Categories Extra info K Mahajan et al. Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. Prostate. 2010, 70(12), 1274-1285.? ? K Mahajan et al. Ack1 mediated androgen receptor phosphorylation modulates radiation resistance in castration resistant prostate cancer. J. Biol. Chem. 2012, 287(26), 22112-22122.? ? K Mahajan, NP Mahajan. Shepherding AKT and androgen receptor by Ack1 tyrosine kinase. J. Cell. Physiol. 2010, 224, 327–333.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Endocrinology ACK1 EC 2.7.10.2 Specific inhibitor of Ack1 tyrosine kinase (also known as TNK2) Chemical name (S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine Parent CAS No. [873305-35-2] Order Size Unit Price Stock 5 mg €95.00 In Stock

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現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

AIM 100

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2031

CAS [873305-35-2]

MF C23H21N3O2
MW 371.43

Purity: 99%
Optical purity: 98.1% e.e.
Soluble in DMSO

AIM 100

Description

Specific inhibitor of Ack1 tyrosine kinase (also known as TNK2); AIM-100 inhibits Ack1 activity and also suppresses androgen receptor (AR) Tyr(267) phosphorylation and its recruitment to the ATM enhancer (Ack1/AR/ATM signaling)

K Mahajan et al. Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. Prostate. 2010, 70(12), 1274-1285.?

K Mahajan et al. Ack1 mediated androgen receptor phosphorylation modulates radiation resistance in castration resistant prostate cancer. J. Biol. Chem. 2012, 287(26), 22112-22122.?

K Mahajan, NP Mahajan. Shepherding AKT and androgen receptor by Ack1 tyrosine kinase. J. Cell. Physiol. 2010, 224, 327–333.?

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Endocrinology ACK1 EC 2.7.10.2

Specific inhibitor of Ack1 tyrosine kinase (also known as TNK2)

Chemical name

(S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine

Parent CAS No.

[873305-35-2]

產(chǎn)品資料

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