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產(chǎn)品名稱

AZD 3463

產(chǎn)品貨號(hào)

Axon 2153 CAS [1356962-20-3] MF C24H25ClN6OMW 448.95 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Potent inhibitor of Anaplastic Lymphoma Kinase (ALK) and IGF1R; AZD3463 is potent in ALK-driven preclinical models and in a variety of crizotinib-resistant models References Certificates Categories Extra info Discovery of AZD3463 as a Novel ALK/IGFR Dual Inhibitor and its Ability in Overcoming Acquired Resistance to Crizotinib. Presented by B Yang at?8th Protein Kinases in Drug Discovery 2013, Boston USA.? ? Concurrent roles for IGF1R and EGFR in driving acquired resistance to crizotinib and ability to overcome with a combination of the ALK/IGF1R inhibitor AZD3463 and Iressa. Abstr. 4465 presented by L Drew et al. AACR Annual Meeting 2013 Washington DC USA.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology ALK Endocrinology TGF-β RTK class II and XIX; EC 2.7.10.1 Potent inhibitor of ALK and IGF1R Chemical name N-(4-(4-aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine Parent CAS No. [1356962-20-3] Order Size Unit Price Stock 5 mg €105.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

AZD 3463

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2153

CAS [1356962-20-3]

MF C24H25ClN6O
MW 448.95

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

AZD 3463

Description

Potent inhibitor of Anaplastic Lymphoma Kinase (ALK) and IGF1R; AZD3463 is potent in ALK-driven preclinical models and in a variety of crizotinib-resistant models

Discovery of AZD3463 as a Novel ALK/IGFR Dual Inhibitor and its Ability in Overcoming Acquired Resistance to Crizotinib. Presented by B Yang at?8th Protein Kinases in Drug Discovery 2013, Boston USA.?

Concurrent roles for IGF1R and EGFR in driving acquired resistance to crizotinib and ability to overcome with a combination of the ALK/IGF1R inhibitor AZD3463 and Iressa. Abstr. 4465 presented by L Drew et al. AACR Annual Meeting 2013 Washington DC USA.?

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology ALK Endocrinology TGF-β RTK class II and XIX; EC 2.7.10.1

Potent inhibitor of ALK and IGF1R

Chemical name

N-(4-(4-aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine

Parent CAS No.

[1356962-20-3]

產(chǎn)品資料

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