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產(chǎn)品名稱

PH 797804

產(chǎn)品貨號

Axon 1837 CAS [586379-66-0] MF C22H19BrF2N2O3MW 477.30 Purity: 99% Soluble in DMSO and ethanol Description Highly potent, selective and metabolically stable inhibitor of p38 MAPK (p38α cascade IC50: 2.3 nM); an ATP-competitive, readily reversible inhibitor of the α isoform of human p38 MAP kinase, exhibiting a Ki of 5.8 nM; clinical candidate. *PH 797804 is an (-)-atropisomer, which is 100-fold more potent than its (+)-atropisomer. Be careful that racemate of PH 797804 is wrongly provided by other supplier as drug PH 797804 itself. The less potent (+)-rotating atropisomer is also available (inquire). Be right about your drug. The racemate,?(±)-PH797804 (Axon 2786) is also available.

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

PH 797804

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1837

CAS [586379-66-0]

MF C22H19BrF2N2O3
MW 477.30

Purity: 99%
Soluble in DMSO and ethanol

PH 797804

Description

Highly potent, selective and metabolically stable inhibitor of p38 MAPK (p38α cascade IC50: 2.3 nM); an ATP-competitive, readily reversible inhibitor of the α isoform of human p38 MAP kinase, exhibiting a Ki of 5.8 nM; clinical candidate.

*PH 797804 is an (-)-atropisomer, which is 100-fold more potent than its (+)-atropisomer. Be careful that racemate of PH 797804 is wrongly provided by other supplier as drug PH 797804 itself. The less potent (+)-rotating atropisomer is also available (inquire). Be right about your drug.

The racemate,?(±)-PH797804 (Axon 2786) is also available.

HR Hope et al. Anti-Inflammatory Properties of a Novel N-Phenyl Pyridinone Inhibitor of p38 Mitogen-Activated Protein Kinase: Preclinical-to-Clinical Translation. J. Pharmacol. Exp. Ther. 2009, 331(3), 882-895.?

SR Selness et al. Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg. Med. Chem. Lett. 2011, 21(13), 4066-4071.?

L Xing et al. Discovery and Characterization of Atropisomer PH-797804, a p38 MAP Kinase Inhibitor, as a Clinical Drug Candidate. ChemMedChem. 2012, 7(2), 273–280.?

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology MAPK (p38) MAPK EC 2.7.11.24

Inhibitor of p38α MAPK

Chemical name

3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide

Parent CAS No.

[586379-66-0]

產(chǎn)品資料

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