| 產(chǎn)品名稱 | GSK 1120212 - Trametinib | JTP 74057 |
| 產(chǎn)品貨號 | Axon 1761 CAS [871700-17-3] MF C26H23FIN5O4MW 615.39 Purity: 99% Soluble in DMSO Description Highly potent and selective MEK inhibitor, with IC50 values to be 0.7 and 0.9 nM for MEK1 and MEK2 respectively and with long circulating half-life References Certificates Categories Extra info AG Gilmartin et al. GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition. Clin. Cancer Res. 2011, 17(5), 989-1000. ? T Yamaguchi et al. Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo. Int J Oncol. 2011, 39(1), 23-31. ? H Abe et al. Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate). ACS Med. Chem. Lett., 2011, 2(4), 320–324. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology MAPK EC 2.7.12.2 MEK MEK1 and MEK2 inhibitor Chemical name N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide Parent CAS No. [871700-17-3] Order Size Unit Price Stock 5 mg €95.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
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| 產(chǎn)品詳情 |
GSK 1120212 - Trametinib | JTP 74057Axon 1761 CAS [871700-17-3] MF C26H23FIN5O4
Description
Highly potent and selective MEK inhibitor, with IC50 values to be 0.7 and 0.9 nM for MEK1 and MEK2 respectively and with long circulating half-life
MEK1 and MEK2 inhibitor
Chemical nameN-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide Parent CAS No.[871700-17-3] |
| 產(chǎn)品資料 |
