| 產(chǎn)品名稱 | JQ-1, (+)- - JQ1 |
| 產(chǎn)品貨號 | Axon 1989 CAS [1268524-70-4] MF C23H25ClN4O2SMW 456.99 Purity: 99% Optical purity: 99% ee Soluble in DMSO Description Potent and selective BET bromodomain inhibitor (IC50 values of 77?nM and 33?nM for inhibition of binding of a tetra-acetylated histone H4 peptide to BRD4 with the first and second bromodomain, respectively). (+)-JQ1 is capable of blocking the macrophage inflammatory responses via inhibition of BET proteins in mice, and activating HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. Cotreatment with JQ1 and the FLT3 inhibitor AC220 (Axon 1696) synergistically induce apoptosis of cultured and primary CD34(+) human AML blast progenitor cells (BPC) expressing FLT3-ITD. KEYWORDS: (+)-JQ-1 | BET inhibitor | JQ1 | JQ-1 | JQ1 | CAS [1268524-70-4] | Histone | BET (BRD) | Inhibitor | Proteins | Bromodomain | inflammatory | HIV latency |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
JQ-1, (+)- - JQ1Axon 1989 CAS [1268524-70-4] MF C23H25ClN4O2S
DescriptionPotent and selective BET bromodomain inhibitor (IC50 values of 77?nM and 33?nM for inhibition of binding of a tetra-acetylated histone H4 peptide to BRD4 with the first and second bromodomain, respectively). (+)-JQ1 is capable of blocking the macrophage inflammatory responses via inhibition of BET proteins in mice, and activating HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. Cotreatment with JQ1 and the FLT3 inhibitor AC220 (Axon 1696) synergistically induce apoptosis of cultured and primary CD34(+) human AML blast progenitor cells (BPC) expressing FLT3-ITD. KEYWORDS: (+)-JQ-1 | BET inhibitor | JQ1 | JQ-1 | JQ1 | CAS [1268524-70-4] | Histone | BET (BRD) | Inhibitor | Proteins | Bromodomain | inflammatory | HIV latency Potent and selective BET bromodomain inhibitor Chemical name(S)-(+)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate Parent CAS No.[1268524-70-4] |
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