| 產(chǎn)品名稱 | OF-1 |
| 產(chǎn)品貨號 | Axon 2442 CAS [919973-83-4] MF C17H18BrN3O4SMW 440.31 Purity: 99% Soluble in DMSO Description Potent Bromodomain inhibitor with selectivity for BRPF1 and BRPF2 (Kd values 100 nM, 500 nM, and 2.4 μM for BRPF1B, BRPF2, and BRPF3, respectively). Selectivity against other bromodomains is very good, in general >100-fold. The closest off-target effects are against BRD4 (39-fold selectivity) and TIF1a (50% inhibition at 20 μM. OF-1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. KEYWORDS: OF1 | supplier | BRPF inhibitor | OF-1 supplier | CAS [919973-83-4] | Histone | BRPF (BRD) | Inhibitor | SGC | Bromodomain | Chromatin | BRPF1 | BRPF1B | BRPF2 | BRD4 | TIF1a | FRAP | epigenetic | DNA |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
OF-1Axon 2442 CAS [919973-83-4] MF C17H18BrN3O4S
DescriptionPotent Bromodomain inhibitor with selectivity for BRPF1 and BRPF2 (Kd values 100 nM, 500 nM, and 2.4 μM for BRPF1B, BRPF2, and BRPF3, respectively). Selectivity against other bromodomains is very good, in general >100-fold. The closest off-target effects are against BRD4 (39-fold selectivity) and TIF1a (50% inhibition at 20 μM. OF-1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. KEYWORDS: OF1 | supplier | BRPF inhibitor | OF-1 supplier | CAS [919973-83-4] | Histone | BRPF (BRD) | Inhibitor | SGC | Bromodomain | Chromatin | BRPF1 | BRPF1B | BRPF2 | BRD4 | TIF1a | FRAP | epigenetic | DNA
Potent bromodomain inhibitor (BRPF1 and BRPF2 selective)
Chemical name4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide Parent CAS No.[919973-83-4] |
| 產(chǎn)品資料 |
