| 產(chǎn)品名稱 | Elacridar hydrochloride - GF 120918A |
| 產(chǎn)品貨號 | Axon 1896 CAS [143851-98-3] MF C34H33N3O5.HClMW 600.10 Purity: 100% Poorly soluble in DMSO Description P-glycoprotein (P-gp) inhibitor; a third generation ABCB1 modulator, preferentially modulating p-gp in brain capillaries; also an inhibitor of breast cancer resistance protein (BCRP)–mediated drug transport References Certificates Categories Extra info IELM Kuppens et al. A Phase I, Randomized, Open-Label, Parallel-Cohort, Dose-Finding Study of Elacridar (GF120918) and Oral Topotecan in Cancer Patients. Clin. Cancer Res. 2007, 13, 3276. ? M Hubensack et al. Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice. J.Cancer Res. Clin. Oncol. 2008, 134(5), 597-607. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS P-glycoprotein Unclassified P-gp inhibitor (3rd generation ABCB1 modulator) Chemical name N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamide hydrochloride Parent CAS No. [143664-11-3] Order Size Unit Price Stock 10 mg €80.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
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| 產(chǎn)品詳情 |
Elacridar hydrochloride - GF 120918AAxon 1896 CAS [143851-98-3] MF C34H33N3O5.HCl
Description
P-glycoprotein (P-gp) inhibitor; a third generation ABCB1 modulator, preferentially modulating p-gp in brain capillaries; also an inhibitor of breast cancer resistance protein (BCRP)–mediated drug transport
P-gp inhibitor (3rd generation ABCB1 modulator)
Chemical nameN-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamide hydrochloride Parent CAS No.[143664-11-3] |
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