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產(chǎn)品名稱

MC70 hydrochloride

產(chǎn)品貨號

Axon 2591 CAS [N.A.] MF C24H25NO3.HClMW 411.92 Purity: 98% Soluble in DMSO Description Potent P-gp inhibitor with good selectivity towards BCRP pump (EC50 values 0.05 μM, 0.69 μM, 9.3 μM, and 73 μM for Caco-2, MDR1, MRP1, and BCRP inhibition, respectively), with potential as novel anticancer agent with both cytostatic and cytotoxic characteristics. MC70, as an inhibitor of the ABC transporter ABCB1 (aka MDR1), potentiates Doxorubicin efficacy in colon and breast cancer in vitro treatment. *Sold in collaboration with Biofordrug srl

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

MC70 hydrochloride

Based on 43 reference(s) in Google Scholar 9 10 43

Axon 2591

CAS [N.A.]

MF C24H25NO3.HCl
MW 411.92

Purity: 98%
Soluble in DMSO

MC70 hydrochloride

Description

Potent P-gp inhibitor with good selectivity towards BCRP pump (EC50 values 0.05 μM, 0.69 μM, 9.3 μM, and 73 μM for Caco-2, MDR1, MRP1, and BCRP inhibition, respectively), with potential as novel anticancer agent with both cytostatic and cytotoxic characteristics. MC70, as an inhibitor of the ABC transporter ABCB1 (aka MDR1), potentiates Doxorubicin efficacy in colon and breast cancer in vitro treatment.

*Sold in collaboration with Biofordrug srl

S Guglielmo et al. A potent and selective P-gp modulator for altering multidrug resistance due to pump overexpression. ChemMedChem. 2016 Feb 17;11(4):374-6.

A Azzariti et al. MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment. Eur J Pharmacol. 2011 Nov 16;670(1):74-84.

NA Colabufo et al. 4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators. Bioorg Med Chem. 2008 Apr 1;16(7):3732-43.

NA Colabufo et al. Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors. ChemMedChem. 2009 Feb;4(2):188-95.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology CNS P-glycoprotein

Potent P-gp inhibitor with good selectivity towards BCRP pump

Chemical name

4'-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl)biphenyl-4-ol hydrochloride

Parent CAS No.

[1031367-64-2]

產(chǎn)品資料

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