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產(chǎn)品名稱

CP 100356 hydrochloride

產(chǎn)品貨號(hào)

Axon 1654 CAS [142715-48-8 ] MF C31H36N4O6.HClMW 597.10 Purity: 98% Soluble in DMSO Description Potent inhibitor of P-glycoprotein (P-gp), with Ki to be 58 and 94 nM for 1a and 1b isomers of P-gp; an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux References Certificates Categories Extra info C Wandel et al. P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. Cancer Res. 1999, 59, 3944. ? JC Taylor et al. The equilibrium and kinetic drug binding properties of the mouse P-gp1a and P-gp1b P-glycoproteins are similar. Br. J. Cancer 1999, 81(5), 783-789. ? AS Kalgutkar et al. N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" (...). J. Pharm. Sci. 2009, 98, 4914. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS P-glycoprotein Unclassified P-gp inhibitor Chemical name 4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-(3,4-dimethoxyphenethyl)-6,7-dimethoxyquinazolin-2-amine Parent CAS No. [142716-85-6] Order Size Unit Price Stock 10 mg €125.00 In Stock

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現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

CP 100356 hydrochloride

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1654

CAS [142715-48-8 ]

MF C31H36N4O6.HCl
MW 597.10

Purity: 98%
Soluble in DMSO

CP 100356 hydrochloride

Description

Potent inhibitor of P-glycoprotein (P-gp), with Ki to be 58 and 94 nM for 1a and 1b isomers of P-gp; an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux

C Wandel et al. P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. Cancer Res. 1999, 59, 3944.

JC Taylor et al. The equilibrium and kinetic drug binding properties of the mouse P-gp1a and P-gp1b P-glycoproteins are similar. Br. J. Cancer 1999, 81(5), 783-789.

AS Kalgutkar et al. N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" (...). J. Pharm. Sci. 2009, 98, 4914.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology CNS P-glycoprotein Unclassified

P-gp inhibitor

Chemical name

4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-(3,4-dimethoxyphenethyl)-6,7-dimethoxyquinazolin-2-amine

Parent CAS No.

[142716-85-6]

產(chǎn)品資料

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