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產(chǎn)品名稱

AZD 7762 hydrochloride

產(chǎn)品貨號

Axon 1399 CAS [860352-01-8] MF C17H19FN4O2S.HClMW 398.88 Purity: 99% Optical purity: >98% ee Soluble in water and DMSO Description Potent and selective inhibitor of checkpoint kinase (CHK; IC50 values 5 nM for Chk1/Chk2). KEYWORDS:?AZD 7762 hydrochloride | supplier | CHK inhibitor | AZD7762 HCl | AZD-7762 | CAS [860352-01-8] | DNA-RNA | checkpoint kinase | CHK1 | CHK2 | stem cell | hematopoetic | HCS

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

AZD 7762 hydrochloride

Based on 275 publications in PubMed 9 10 275

Axon 1399

CAS [860352-01-8]

MF C17H19FN4O2S.HCl
MW 398.88

Purity: 99%
Optical purity: >98% ee
Soluble in water and DMSO

AZD 7762 hydrochloride

Description

Potent and selective inhibitor of checkpoint kinase (CHK; IC50 values 5 nM for Chk1/Chk2).

KEYWORDS:?AZD 7762 hydrochloride | supplier | CHK inhibitor | AZD7762 HCl | AZD-7762 | CAS [860352-01-8] | DNA-RNA | checkpoint kinase | CHK1 | CHK2 | stem cell | hematopoetic | HCS

JW Janetka et al, Inhibitors of Checkpoint Kinases: From discovery to the clinic. Curr. Opin. Drug Discov. & Devel. 2007, 10(4), 473-486.

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S. Ashwell and S Zabludoff. DNA Damage Detection and Repair Pathways Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy. Clin. Cancer Res. 2008, 14(13), 4033-4037.

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SD Zabludoff et al.?AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies.?Mol. Cancer Ther. 2008, 7(9), 2955-2966.

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L Carrassa et al. Role of Chk1 in the differentiation program of hematopoietic stem cells. Cell. Mol. Life Sci. 2010, 67, 1713–1722.

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List of publications using AZD 7762 (Axon 1399) purchased from Axon Medchem

Certificate of Analysis
Material Safety Data Sheet

Cell Cycle Regulation Cell Signaling & Oncology Stem Cell p53-Tumor Suppression DNA-damage Response EC 2.7.11.1 CHK

CHK inhibitor

Chemical name

5-(3-Fluoro-phenyl)-3-ureido-thiophene-2-carboxylic acid (S)-piperidin-3-ylamide hydrochloride

Parent CAS No.

[860352-01-8]

產(chǎn)品資料

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