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產(chǎn)品名稱(chēng)

BIX 02189

產(chǎn)品貨號(hào)

Axon 1809 CAS [1094614-85-3] MF C27H28N4O2MW 440.54 Purity: 99% Soluble in DMSO Description Selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively References Certificates Categories Extra info RJ Tatake et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem. Biophys. Res. Comm. 2008, 377(1),?120–125. ? Y Obara and N Nakahata. The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effects. Mol. Pharmacol. 2010, 77(1), 10-16.?? ? BA Drew, ME Burowa , BS Beckman. MEK5/ERK5 pathway: The first fifteen years. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2012, 1825 (1), 37-48. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Stem Cell MAPK EC 2.7.12.2 ERK MEK MEK5 inhibitor; ERK5 inhibitor Chemical name ((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide Parent CAS No. [1094614-85-3 1265916-41-3 (Z-isomer)] Order Size Unit Price Stock 5 mg €125.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

BIX 02189

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1809

CAS [1094614-85-3]

MF C27H28N4O2
MW 440.54

Purity: 99%
Soluble in DMSO

BIX 02189

Description

Selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively

RJ Tatake et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem. Biophys. Res. Comm. 2008, 377(1),?120–125.

Y Obara and N Nakahata. The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effects. Mol. Pharmacol. 2010, 77(1), 10-16.??

BA Drew, ME Burowa , BS Beckman. MEK5/ERK5 pathway: The first fifteen years. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2012, 1825 (1), 37-48.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Stem Cell MAPK EC 2.7.12.2 ERK MEK

MEK5 inhibitor; ERK5 inhibitor

Chemical name

((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide

Parent CAS No.

[1094614-85-3 1265916-41-3 (Z-isomer)]

產(chǎn)品資料

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