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產(chǎn)品名稱

Ferrostatin 1 - Fer-1

產(chǎn)品貨號

Axon 2293 CAS [347174-05-4] MF C15H22N2O2MW 262.35 Purity: 99% Soluble in DMSO Description Potent inhibitor of erastin-induced ferroptosis, an iron dependent form of cell death morphologically, biochemically and genetically distinct from apoptosis, various forms of necrosis, and autophagy (EC50 value 60 nM in HT-1080 cells). Ferrostatin-1 specifically inhibits cell death induced by RAS-selective lethal compounds (RSLs), but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Ferrostatin-1 does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells, nor does it chelate iron or inhibit protein synthesis. It is capable of blocking the cytotoxic effects of Sorafenib (Axon 1397) in HCC cells. KEYWORDS: Ferrostatin 1 | supplier | Ferroptosis inhibitor | Fer1 |CAS[347174-05-4] |RAS proteins | Inhibitor | Apoptosis | ROS | RAS-related | nonapoptotic | RSL | Erastin induced | oxidative | cell death | cancer |Huntington's | HD | PUFA | Sorafenib

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Ferrostatin 1 - Fer-1

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2293

CAS [347174-05-4]

MF C15H22N2O2
MW 262.35

Purity: 99%
Soluble in DMSO

Ferrostatin 1

Description

Potent inhibitor of erastin-induced ferroptosis, an iron dependent form of cell death morphologically, biochemically and genetically distinct from apoptosis, various forms of necrosis, and autophagy (EC50 value 60 nM in HT-1080 cells). Ferrostatin-1 specifically inhibits cell death induced by RAS-selective lethal compounds (RSLs), but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Ferrostatin-1 does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells, nor does it chelate iron or inhibit protein synthesis. It is capable of blocking the cytotoxic effects of Sorafenib (Axon 1397) in HCC cells.

S.J. Dixon et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012, 149, 1060-1072.

R. Skouta et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J. Am. Chem Soc. 2014, 136, 4551-4556.

C. Louandre et al. Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib. Int. J. Cancer. 2013, 133, 1732-1742.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology CNS Ferroptosis

Potent inhibitor of erastin-induced ferroptosis

Chemical name

Ethyl 3-amino-4-(cyclohexylamino)benzoate

Parent CAS No.

[347174-05-4]

產(chǎn)品資料

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