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產(chǎn)品名稱

IM 12

產(chǎn)品貨號(hào)

Axon 2511 CAS [1129669-05-1] MF C22H20FN3O2MW 377.41 Purity: 99% Soluble in DMSO Description GSK-3β inhibitor (IC50 value 53 nM) showing a bell-shaped dose-response relationship. IM12 enhances canonical Wnt signalling, and attenuates cell proliferation and neuronal differentiation of human neural progenitor cells with similar potency as SB 216763 (Axon 1303). *Promotion

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現(xiàn)貨詢價(jià)，電話：010-67529703

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產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

IM 12

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2511

CAS [1129669-05-1]

MF C22H20FN3O2
MW 377.41

Purity: 99%
Soluble in DMSO

IM 12

Description

GSK-3β inhibitor (IC50 value 53 nM) showing a bell-shaped dose-response relationship. IM12 enhances canonical Wnt signalling, and attenuates cell proliferation and neuronal differentiation of human neural progenitor cells with similar potency as SB 216763 (Axon 1303).

*Promotion: IM 12 is an important componant of Inhibitor Set(s):

Axon 5011

A.C. Schm?le et al. Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. Bioorg Med Chem. 2010 Sep 15;18(18):6785-95.

A. Brennführer et al. Catalytic and Stoichiometric Synthesis of Novel 3-Aminocarbonyl-, 3-Alkoxycarbonyl-, and 3-Amino-4-indolylmaleimides. Eur. J. Org. Chem., 2009: 38-42.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology CNS Diabetes & Metabolism Immunology Pain & Inflammation Stem Cell GSK-3 Wnt-β-Catenin PI3K-Akt-mTOR EC 2.7.11.26

GSK-3β inhibitor attenuating neuronal differentiation of human NPCs

Chemical name

3-(4-fluorophenethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Parent CAS No.

[1129669-05-1]

產(chǎn)品資料

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