| 產(chǎn)品名稱 | Kobe 0065 |
| 產(chǎn)品貨號 | Axon 2302 CAS [436133-68-5] MF C15H11ClF3N5O4SMW 449.79 Purity: 99% Soluble in DMSO Description Orally active RAS inhibitor with selectivity for HRAS (Ki value of 46 ± 13 μM ) that effectively inhibits both anchorage-dependent and -independent growth and induces apoptosis of H-rasG12V–transformed NIH 3T3 cells. This results in down-regulation of downstream molecules such as MEK/ERK, Akt, and RalA as well as an upstream molecule, Son of sevenless. Kobe 0065 exhibits antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-rasG12V gene by oral administration. References Certificates Categories Extra info F. Shima et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. PNAS U.S.A. 2013, 110, 8182-8187. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology MAPK EC 3.6.5.2 HRAS HRAS inhibitor Chemical name N-(3-chloro-4-methylphenyl)-2-(2,6-dinitro-4-(trifluoromethyl)phenyl)hydrazinecarbothioamide Parent CAS No. [436133-68-5] Order Size Unit Price Stock 10 mg €70.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Kobe 0065Axon 2302 CAS [436133-68-5] MF C15H11ClF3N5O4S
Description
Orally active RAS inhibitor with selectivity for HRAS (Ki value of 46 ± 13 μM ) that effectively inhibits both anchorage-dependent and -independent growth and induces apoptosis of H-rasG12V–transformed NIH 3T3 cells. This results in down-regulation of downstream molecules such as MEK/ERK, Akt, and RalA as well as an upstream molecule, Son of sevenless. Kobe 0065 exhibits antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-rasG12V gene by oral administration.
HRAS inhibitor
Chemical nameN-(3-chloro-4-methylphenyl)-2-(2,6-dinitro-4-(trifluoromethyl)phenyl)hydrazinecarbothioamide Parent CAS No.[436133-68-5] |
| 產(chǎn)品資料 |
