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產(chǎn)品名稱

TIC 10 active isomer - Angular TIC 10 | Active isomer 2

產(chǎn)品貨號

Axon 2300 CAS [1616632-77-9] MF C24H26N4OMW 386.49 Purity: 99% Soluble in DMSO Description Potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner. TIC10/ONC201 inactivates kinases Akt and extracellular signal–regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. Efficacious antitumor therapeutic agent Prime Source Information:

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axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

TIC 10 active isomer - Angular TIC 10 | Active isomer 2

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2300

CAS [1616632-77-9]

MF C24H26N4O
MW 386.49

Purity: 99%
Soluble in DMSO

TIC 10 active isomer

Description

Potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner. TIC10/ONC201 inactivates kinases Akt and extracellular signal–regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. Efficacious antitumor therapeutic agent

Prime Source Information:
Axon 2300 is the confirmed 'angular' bio-active regio-isomer '2' as identified in the recently published issue of Angew. Chem. 2014, 126, 6746 –6749!

N.T. Jacob et al. Pharmacophore Reassignment for Induction of the Immunosurveillance Cytokine TRAIL. Angew. Chem. 2014, 126, 6746 –6749.

J.E. Allen et al. Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects.?Sci. Transl. Med. 2013, 5, 171ra17.?

J.E. Allen. Efficacy and mechanistic evaluation of TIC10, a novel antitumor agent. Dissertation Univ. Pennsylvania 2012.?

VV Prabhu et al. Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner. Cancer Res. 2015 Apr 1;75(7):1423-32.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology TRAIL MAPK PI3K-Akt-mTOR Unclassified

Small molecule that transcriptionally induces TRAIL

Chemical name

7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one

Parent CAS No.

[1616632-77-9]

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