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產(chǎn)品名稱

WP 1066

產(chǎn)品貨號(hào)

Axon 2316 CAS [857064-38-1] MF C17H14BrN3OMW 356.22 Purity: 99% Optical purity: Optically pure Soluble in DMSO and Ethanol Description Potent inhibitor of JAK2 and STAT3 activity (IC50 values 2.3 μM and 5.6 μM, respectively) that showed selective cytotoxicity toward malignant glioma U87-MG and U373-MG cells at much lower doses than its analogue AG 490 (Axon 1378). Furthermore, WP1066 selectively induces apoptosis in malignant glioma cells by downregulating antiapoptotic proteins (Bcl-XL, Mcl-1 and c-myc) and activating Bax, and significantly inhibited the growth of subcutaneous tumors generated from U87-MG cells in mice. References Certificates Categories Extra info A. Iwamaru et al. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene. 2007, 26, 2435-2444. ? M.A. Hatiboglu et al. The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models. Int. J. Cancer. 2012, 131, 8-17. ? S. Verstovsek et al. WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin. Cancer Res. 2008, 14, 788-796. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Immunology Stem Cell Transcription Factors JAK-STAT EC 2.7.10.2 STAT3 JAK Potent JAK2 and STAT3 inhibitor and downregulator of antiapoptotic proteins Chemical name (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide Parent CAS No. [857064-38-1] Order Size Unit Price Stock 10 mg €95.00 In Stock

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現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

WP 1066

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2316

CAS [857064-38-1]

MF C17H14BrN3O
MW 356.22

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO and Ethanol

WP 1066

Description

Potent inhibitor of JAK2 and STAT3 activity (IC50 values 2.3 μM and 5.6 μM, respectively) that showed selective cytotoxicity toward malignant glioma U87-MG and U373-MG cells at much lower doses than its analogue AG 490 (Axon 1378). Furthermore, WP1066 selectively induces apoptosis in malignant glioma cells by downregulating antiapoptotic proteins (Bcl-XL, Mcl-1 and c-myc) and activating Bax, and significantly inhibited the growth of subcutaneous tumors generated from U87-MG cells in mice.

A. Iwamaru et al. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene. 2007, 26, 2435-2444.

M.A. Hatiboglu et al. The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models. Int. J. Cancer. 2012, 131, 8-17.

S. Verstovsek et al. WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin. Cancer Res. 2008, 14, 788-796.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology Immunology Stem Cell Transcription Factors JAK-STAT EC 2.7.10.2 STAT3 JAK

Potent JAK2 and STAT3 inhibitor and downregulator of antiapoptotic proteins

Chemical name

(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide

Parent CAS No.

[857064-38-1]

產(chǎn)品資料

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