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產(chǎn)品名稱

Fendiline hydrochloride

產(chǎn)品貨號(hào)

Axon 2829 CAS [13636-18-5] MF C23H25N.HClMW 351.91 Purity: 99% Soluble in DMSO Description Fendiline, an L-type calcium channel blocker (IC50 value of 17 μM), is a specific inhibitor of K-Ras plasma membrane targeting (IC50 value of 9.64 μM) with no detectable effect on the localization of H- and N-Ras. Moreover, Fendiline blocked the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras. KEYWORDS: Fendiline hydrochloride | supplier | KRAS inhibitor | CAS [13636-18-5] | [13042-18-7] | GTP | KRAS | Inhibitor | Enzymes | Calcium Channel blocker | Ca2+ | GTPase | K-Ras

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Fendiline hydrochloride

Based on 452 reference(s) in Google Scholar 8 10 452

Axon 2829

CAS [13636-18-5]

MF C23H25N.HCl
MW 351.91

Purity: 99%
Soluble in DMSO

Fendiline hydrochloride

Description

Fendiline, an L-type calcium channel blocker (IC50 value of 17 μM), is a specific inhibitor of K-Ras plasma membrane targeting (IC50 value of 9.64 μM) with no detectable effect on the localization of H- and N-Ras. Moreover, Fendiline blocked the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras.

R Bayer et al. Fendiline: a review of its basic pharmacological and clinical properties. Pharmatherapeutica. 1987;5(2):103-36.

O Tripathi et al. Fendiline inhibits L-type calcium channels in guinea-pig ventricular myocytes: a whole-cell patch-clamp study. Br J Pharmacol. 1993 Apr;108(4):865-9.

D van der Hoeven et al. Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol Cell Biol. 2013 Jan;33(2):237-51.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular Cell Signaling & Oncology MAPK EC 3.6.5.2 KRAS

KRAS inhibitor; Ca2+ channel blocker (L-type voltage gated)

Chemical name

3,3-Diphenyl-N-(1-phenylethyl)propan-1-amine hydrochloride

Parent CAS No.

[13042-18-7]

產(chǎn)品資料

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