| 產(chǎn)品名稱(chēng) | APS-2-79 |
| 產(chǎn)品貨號(hào) | Axon 2611 CAS [2002381-31-7] MF C23H21N3O3.HClMW 423.89 Purity: 98% Soluble in DMSO Description Small molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2). Furthermore, APS-2-79 modulates KSR-dependent MAPK signaling, and increases the potency of several MEK inhibitors, specifically within Ras-mutant cell lines by antagonizing release of negative feedback signaling. KEYWORDS:?APS-2-79 | supplier | KSR/Raf inhibitor | APS2-79 | CAS [2002381-31-7] | [ 2002381-25-9] | MEK | KSR2 | Kinase suppressor of Ras | Raf | MAPK | K-Ras | mitogen activated | oncogenic |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢(xún)價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
APS-2-79Axon 2611 CAS [2002381-31-7] MF C23H21N3O3.HCl
DescriptionSmall molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2). Furthermore, APS-2-79 modulates KSR-dependent MAPK signaling, and increases the potency of several MEK inhibitors, specifically within Ras-mutant cell lines by antagonizing release of negative feedback signaling. KEYWORDS:?APS-2-79 | supplier | KSR/Raf inhibitor | APS2-79 | CAS [2002381-31-7] | [ 2002381-25-9] | MEK | KSR2 | Kinase suppressor of Ras | Raf | MAPK | K-Ras | mitogen activated | oncogenic
Inhibitor of KSR and oncogenic Ras signaling
Chemical name6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine hydrochloride Parent CAS No.[ 2002381-25-9] |
| 產(chǎn)品資料 |
