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產(chǎn)品名稱

LB 42708

產(chǎn)品貨號

Axon 1794 CAS [226929-39-1] MF C30H27BrN4O2MW 555.46 Purity: 99% Soluble in DMSO Description Selective and orally available inhibitor of farnesyltransferase (FTase), with IC50 values of 0.8 nM in vitro and 8 nM in cultured cells against p21-ras farnesylation References Certificates Categories Extra info HJ Na et al. Inhibition of Farnesyltransferase Prevents Collagen-Induced Arthritis by Down-Regulation of Inflammatory Gene Expression through Suppression of p21ras-Dependent NF-κB Activation. J. Immunol. 2004, 173, 1276-1283.? ? CK Kim et al. The farnesyltransferase inhibitor LB42708 suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting Ras-dependent mitogen-activated protein kinase and PI3K/Akt signal pathways. Mol. Pharmacol. 2010, 78, 142-150.?? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Farnesyltransferase EC 2.5.1.58 Inhibitor of farnesyltransferase (FTase) Chemical name (1-((1-(4-bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone Parent CAS No. [226929-39-1] Order Size Unit Price Stock 5 mg €95.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

LB 42708

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1794

CAS [226929-39-1]

MF C30H27BrN4O2
MW 555.46

Purity: 99%
Soluble in DMSO

LB 42708

Description

Selective and orally available inhibitor of farnesyltransferase (FTase), with IC50 values of 0.8 nM in vitro and 8 nM in cultured cells against p21-ras farnesylation

HJ Na et al. Inhibition of Farnesyltransferase Prevents Collagen-Induced Arthritis by Down-Regulation of Inflammatory Gene Expression through Suppression of p21ras-Dependent NF-κB Activation. J. Immunol. 2004, 173, 1276-1283.?

CK Kim et al. The farnesyltransferase inhibitor LB42708 suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting Ras-dependent mitogen-activated protein kinase and PI3K/Akt signal pathways. Mol. Pharmacol. 2010, 78, 142-150.??

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Farnesyltransferase EC 2.5.1.58

Inhibitor of farnesyltransferase (FTase)

Chemical name

(1-((1-(4-bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone

Parent CAS No.

[226929-39-1]

產(chǎn)品資料

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