| 產(chǎn)品名稱 | Erastin |
| 產(chǎn)品貨號 | Axon 1825 CAS [571203-78-6] MF C30H31ClN4O4MW 547.04 Purity: 99% Soluble in DMSO Description An anti-tumor agent with RAS-selective lethality. Erastin binds to mitochondrial voltage-dependent anion channels (VDAC) proteins, more specifically on VDAC2 and alters its gating; induce non-apoptotic cell death selectively in some tumour cells harbouring activating mutations in the RAS-RAF-MEK pathway References Certificates Categories Extra info N Yagoda et al. RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 2007, 447, 865-869.? ? Citation: JF Foley, Selective Killing. Sci. STKE 2007, 391, p. tw212.? ? E imamura et al. Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents. J. Bioenerg. Biomembr. 2008, 40(3), 213-217.? Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology VDAC2 Unclassified VDAC2 modulator Chemical name 4(3H)-Quinazolinone, 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)- Parent CAS No. [571203-78-6] Order Size Unit Price Stock 5 mg €95.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
ErastinAxon 1825 CAS [571203-78-6] MF C30H31ClN4O4
Description
An anti-tumor agent with RAS-selective lethality. Erastin binds to mitochondrial voltage-dependent anion channels (VDAC) proteins, more specifically on VDAC2 and alters its gating; induce non-apoptotic cell death selectively in some tumour cells harbouring activating mutations in the RAS-RAF-MEK pathway
VDAC2 modulator
Chemical name4(3H)-Quinazolinone, 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)- Parent CAS No.[571203-78-6] |
| 產(chǎn)品資料 |
