| 產(chǎn)品名稱 | JNK-IN-8 |
| 產(chǎn)品貨號 | Axon 2361 CAS [1410880-22-6] MF C29H29N7O2MW 507.59 Purity: 98% Soluble in DMSO Description Remarkably potent and selective covalent inhibitor of JNK (IC50 values 4.67 nM, 18.7 nM, and 0.98nM for JNK1/2/3, respectively). JNK-IN-8 inhibits phosphorylation of c-Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue (EC50 values 486 nM and 338 nM for inhibition of c-Jun phosphorylation in HeLa and A375 cells, respectively). Useful as a pharmacological probe of JNK-dependent signal transduction References Certificates Categories Extra info T. Zhang et al. Discovery of potent and selective covalent inhibitors of JNK. Chem. Biol. 2012, 19, 140-154. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology CNS Immunology Pain & Inflammation MAPK (JNK) p53-Tumor Suppression NF-κB MAPK EC 2.7.11.24 Remarkably potent and selective covalent inhibitor of JNK Chemical name (E)-3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide Parent CAS No. [1410880-22-6] Order Size Unit Price Stock 5 mg €120.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
JNK-IN-8Axon 2361 CAS [1410880-22-6] MF C29H29N7O2
Description
Remarkably potent and selective covalent inhibitor of JNK (IC50 values 4.67 nM, 18.7 nM, and 0.98nM for JNK1/2/3, respectively). JNK-IN-8 inhibits phosphorylation of c-Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue (EC50 values 486 nM and 338 nM for inhibition of c-Jun phosphorylation in HeLa and A375 cells, respectively).
Useful as a pharmacological probe of JNK-dependent signal transduction
Remarkably potent and selective covalent inhibitor of JNK
Chemical name(E)-3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide Parent CAS No.[1410880-22-6] |
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