| 產(chǎn)品名稱 | A 83-01 |
| 產(chǎn)品貨號 | Axon 1421 CAS [909910-43-6] MF C25H19N5SMW 421.52 Purity: 99% Soluble in DMSO Description Potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 and its relatives ALK4 and ALK7 (IC50 to be 12, 45 and 7.5 nM respectively). A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β, but had no effect on BMP signaling; Used to generate rat and human iPS cells towards a mouse ES cell like self-renewal state. *Note: A 83-01 is found to decompose to A 77-01 (Axon 1744) in solution slowly. Hence freshly prepared solution is highly recommended and otherwise, its stock solution in DMSO needs to be stored <-20 °C (not longer than 1 month).? KEYWORDS:?A 83-01 | supplier | ALK5 inhibitor | A83-01 | A8301 | CAS [909910-43-6] | TGF-β | TGF-βR | Antagonist | ALK4 | ALK7 | Smad | signaling | epithelial | mesenchymal | transition | iPS | self-renewal |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
A 83-01Axon 1421 CAS [909910-43-6] MF C25H19N5S
DescriptionPotent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 and its relatives ALK4 and ALK7 (IC50 to be 12, 45 and 7.5 nM respectively). A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β, but had no effect on BMP signaling; Used to generate rat and human iPS cells towards a mouse ES cell like self-renewal state. *Note: A 83-01 is found to decompose to A 77-01 (Axon 1744) in solution slowly. Hence freshly prepared solution is highly recommended and otherwise, its stock solution in DMSO needs to be stored <-20 °C (not longer than 1 month).? KEYWORDS:?A 83-01 | supplier | ALK5 inhibitor | A83-01 | A8301 | CAS [909910-43-6] | TGF-β | TGF-βR | Antagonist | ALK4 | ALK7 | Smad | signaling | epithelial | mesenchymal | transition | iPS | self-renewal
TGF-βR 1 inhibitor; ALK 5 inhibitor
Chemical name3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide Parent CAS No.[909910-43-6] |
| 產(chǎn)品資料 |
