| 產(chǎn)品名稱 | Tacalcitol - PRI 2191 | 1α,24-Dihydroxycholecalciferol |
| 產(chǎn)品貨號(hào) | Axon 2516 CAS [57333-96-7] MF C27H44O3MW 416.64 Purity: 98% Soluble in DMSO Description Vitamine D receptor agonist (EC50 value 7 nM for VDR) and metabolite of vitamin D3 with a higher antitumor and lower calcemic activity as well as lower toxicity than Calcitriol. Tacalcitol inhibits proliferation and induces differentiation of keratinocytes. Tacalcitol (PRI 2191) promotes normal bone formation, and is a well-known inhibitor of chemical mediated inflammatory changes including dermal cellular infiltration and epidermal hyperplasia, used to treat T cell-mediated inflammatory skin diseases such as psoriasis, prurigo and vitiligo. PRI2191 enhances the antiproliferative effect of Imatinib (Axon 1394) on HL-60 cells. Note: |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Tacalcitol - PRI 2191 | 1α,24-DihydroxycholecalciferolAxon 2516 CAS [57333-96-7] MF C27H44O3
DescriptionVitamine D receptor agonist (EC50 value 7 nM for VDR) and metabolite of vitamin D3 with a higher antitumor and lower calcemic activity as well as lower toxicity than Calcitriol. Tacalcitol inhibits proliferation and induces differentiation of keratinocytes. Tacalcitol (PRI 2191) promotes normal bone formation, and is a well-known inhibitor of chemical mediated inflammatory changes including dermal cellular infiltration and epidermal hyperplasia, used to treat T cell-mediated inflammatory skin diseases such as psoriasis, prurigo and vitiligo. PRI2191 enhances the antiproliferative effect of Imatinib (Axon 1394) on HL-60 cells. Note: Axon 2516 is the stable monohydrate formulation of Tacalcitol KEYWORDS: Tacalcitol | Supplier | VDR agonist | Axon Medchem | Axon 2516 | PRI 2191 | 1α | 24-Dihydroxycholecalciferol | PRI2191 | CAS [57333-96-7] [93129-94-3]?| Calcitriol | VDR | Agonist | Vitamine D3 | inflammation | psoriasis | antiproliferate | antitumor | calcium | differentiation
Vitamine D receptor (VDR) agonist with antitumor activity
Chemical name(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,5R)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Parent CAS No.[57333-96-7] |
| 產(chǎn)品資料 |
