| 產(chǎn)品名稱 | WDR5-0103 |
| 產(chǎn)品貨號 | Axon 2411 CAS [890190-22-4] MF C21H25N3O4MW 383.44 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Inhibitor of WD40 repeat protein 5 (WDR5) and associated activity of H3K4 HMTase MLL (Kd value 0.45 μM for WDR5 binding, and IC50 value of 39 μM for inhibition of methyltransferase activity of MLL complex). Potential therapeutic for treatment of MLL-rearranged leukemias or other cancers. References Certificates Categories Extra info G. Senisterra et al. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem J. 2013 Jan 1;449(1):151-9. ? Y. Bolshan et al. Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction. ACS Med Chem Lett. 2013 Feb 4;4(3):353-7. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Epigenetics WDR5 Inhibitor of WD40 repeat protein 5 (WDR5) and associated activity of H3K4 HMTase MLL Chemical name methyl 3-(3-methoxybenzamido)-4-(4-methylpiperazin-1-yl)benzoate Parent CAS No. [890190-22-4] Order Size Unit Price Stock 10 mg €90.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
WDR5-0103Axon 2411 CAS [890190-22-4] MF C21H25N3O4
Description
Inhibitor of WD40 repeat protein 5 (WDR5) and associated activity of H3K4 HMTase MLL (Kd value 0.45 μM for WDR5 binding, and IC50 value of 39 μM for inhibition of methyltransferase activity of MLL complex). Potential therapeutic for treatment of MLL-rearranged leukemias or other cancers.
Inhibitor of WD40 repeat protein 5 (WDR5) and associated activity of H3K4 HMTase MLL
Chemical namemethyl 3-(3-methoxybenzamido)-4-(4-methylpiperazin-1-yl)benzoate Parent CAS No.[890190-22-4] |
| 產(chǎn)品資料 |
