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產(chǎn)品名稱

RG 108

產(chǎn)品貨號(hào)

Axon 1691 CAS [48208-26-0] MF C19H14N2O4MW 334.33 Purity: 99% Optical purity: >98% ee Soluble in DMSO Description DNA methyltransferase inhibitor; Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity; Demethylates and reactivates epigenetically silenced tumor suppressor genes. Recently, BIX01294 (Axon 1692) ?and RG108 have been reported to enhance the efficiency of induced pluripotent stem cell (iPS) generation *Promotion

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

RG 108

Based on 211 publications in PubMed 10 10 211

Axon 1691

CAS [48208-26-0]

MF C19H14N2O4
MW 334.33

Purity: 99%
Optical purity: >98% ee
Soluble in DMSO

RG 108

Description

DNA methyltransferase inhibitor; Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity; Demethylates and reactivates epigenetically silenced tumor suppressor genes.
Recently, BIX01294 (Axon 1692) ?and RG108 have been reported to enhance the efficiency of induced pluripotent stem cell (iPS) generation

*Promotion: RG 108 is also part of Inhibitor Set(s):

Axon 5008

B Brueckner et al. Epigenetic Reactivation of Tumor Suppressor Genes by a Novel Small-Molecule Inhibitor of Human DNA Methyltransferases. Cancer Res. 2005, 65, 6305-6311.

C Stresemann et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res 2006, 66(5), 2794-2800.

Y Shi et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 2008, 3, 568-574.

Y Shi et al. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell. 2008, 2(6), 525-528.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Epigenetics Stem Cell EC 2.1.1.37 DNA methyltransferase

DNA methyltransferase inhibitor

Chemical name

(S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid

Parent CAS No.

[48208-26-0]

產(chǎn)品資料

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