產(chǎn)品名稱

GSK 690693

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Axon 1729 CAS [937174-76-0] MF C21H27N7O3MW 425.48 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Potent and ATP-competitive Akt kinase inhibitor, with IC50 to be 2, 13 and 9 nM for Akt1, Akt2 and Akt3 respectively References Certificates Categories Extra info N Rhodes et al. Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity. Cancer Res. 2008, 68(7), 2366-2374. ? DA Heerding et al. Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J. Med. Chem. 2008, 51(18), 5663-5679. ? DS Lew et al. AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Blood. 2009, 113(8), 1723-1729. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Akt PI3K-Akt-mTOR EC 2.7.11.1 ATP-competitive pan-Akt kinase inhibitor Chemical name (S)-4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol Parent CAS No. [937174-76-0] Order Size Unit Price Stock 5 mg €115.00 In Stock

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axonmedchem

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