| 產(chǎn)品名稱 | Pexidartinib - PLX 3397 |
| 產(chǎn)品貨號 | Axon 2501 CAS [1029044-16-3] MF C20H15ClF3N5MW 417.81 Purity: 99% Soluble in DMSO Description Multi-targeted receptor tyrosine kinase inhibitor of CSF1R, c-Kit, and FLT3 (IC50 values 13 nM, 27 nM, and 11 nM, respectively) Administration of PLX3397 reduced CIBP, induced substantial intratumoral fibrosis, and was also highly efficacious in reducing tumor cell growth, formation of new tumor colonies in bone, and pathological tumor-induced bone remodeling. PLX3397 is superior to imatinib in the treatment of malignant peripheral nerve sheath tumor (MPNST), and the combination of PLX3397 with a TORC1 inhibitor could provide a new therapeutic approach for the treatment of this disease. KEYWORDS:?Pexidartinib | supplier | RTK inhibitor | PLX 3397 | PLX3397 | CAS [1029044-16-3] | FLT3LG | FLT3 | c-KIT | CSF1R | cytokine | tyrosine kinase | CIBP | MPNST | TORC1 | cluster of differentiation | hematopoietic | stem cell factor | SCF |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Pexidartinib - PLX 3397Axon 2501 CAS [1029044-16-3] MF C20H15ClF3N5
DescriptionMulti-targeted receptor tyrosine kinase inhibitor of CSF1R, c-Kit, and FLT3 (IC50 values 13 nM, 27 nM, and 11 nM, respectively) Administration of PLX3397 reduced CIBP, induced substantial intratumoral fibrosis, and was also highly efficacious in reducing tumor cell growth, formation of new tumor colonies in bone, and pathological tumor-induced bone remodeling. PLX3397 is superior to imatinib in the treatment of malignant peripheral nerve sheath tumor (MPNST), and the combination of PLX3397 with a TORC1 inhibitor could provide a new therapeutic approach for the treatment of this disease. KEYWORDS:?Pexidartinib | supplier | RTK inhibitor | PLX 3397 | PLX3397 | CAS [1029044-16-3] | FLT3LG | FLT3 | c-KIT | CSF1R | cytokine | tyrosine kinase | CIBP | MPNST | TORC1 | cluster of differentiation | hematopoietic | stem cell factor | SCF
Mutil-targeted RTK inhibitor of CSF1R, c-Kit, and FLT3
Chemical name5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine Parent CAS No.[1029044-16-3] |
| 產(chǎn)品資料 |
