| 產(chǎn)品名稱 | TM 5275 |
| 產(chǎn)品貨號 | Axon 2344 CAS [1103926-82-4] MF C28H27ClN3NaO5MW 543.97 Purity: 99% Soluble in DMSO Description Selective, orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 value 6.95 μM in tissue plasminogen activator-dependent peptide hydrolysis essay) with antithrombotic benefits devoid of bleeding effect in rodents and nonhuman primates, and with impressive bioavailability.TM 5275 prolongs tPA retention and enhances plasmin generation on the vascular endothelial cell (VEC) surface as a result of PAI-1 inhibition.Additionally, TM 5275 represents a novel class of anti-inflammatory agents targeting macrophage migration by the inhibition of the interaction of PAI-1 with low-density lipoprotein receptor–related protein (IC50 values 3.13 μM and 3.02 μM for LRP1 protein Cl II and Cl IV, respectively). References Certificates Categories Extra info Y. Izuhara et al. A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates. J. Cereb. Blood Flow Metab. 2010, 30, 904-912. ? H. Yasui et al. TM5275 prolongs secreted tissue plasminogen activator retention and enhances fibrinolysis on vascular endothelial cells. Thromb. Res. 2013, 132, 100-105. ? A. Ichimura et al. A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration. Arterioscler. Thromb. Vasc. Biol. 2013, 33, 935-942. Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Signaling & Oncology Miscellaneous Pain & Inflammation Plasminogen activator inhibitor-1 (PAI-1) EC 3.4.21 Selective and orally active inhibitor of PAI-1 Chemical name Sodium 2-(2-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy)acetamido)-5-chlorobenzoate Parent CAS No. [1103928-13-7] Order Size Unit Price Stock 5 mg €105.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
TM 5275Axon 2344 CAS [1103926-82-4] MF C28H27ClN3NaO5
DescriptionSelective, orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 value 6.95 μM in tissue plasminogen activator-dependent peptide hydrolysis essay) with antithrombotic benefits devoid of bleeding effect in rodents and nonhuman primates, and with impressive bioavailability.TM 5275 prolongs tPA retention and enhances plasmin generation on the vascular endothelial cell (VEC) surface as a result of PAI-1 inhibition.
Selective and orally active inhibitor of PAI-1
Chemical nameSodium 2-(2-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy)acetamido)-5-chlorobenzoate Parent CAS No.[1103928-13-7] |
| 產(chǎn)品資料 |
