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產(chǎn)品名稱

E 5555 hydrobromide - Atopaxar hydrobromide

產(chǎn)品貨號

Axon 2030 CAS [474550-69-1] MF C29H38FN3O5.HBrMW 608.54 Purity: 99% Soluble in DMSO Description Potent and orally active thrombin receptor (or protease-activated receptor 1, PAR1) antagonist (IC50: 19 nM); E5555 showed potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 values of 64 and 31nM, respectively References Certificates Categories Extra info LV Serebruany et al. The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease. Thromb. Haemost. 2009, 102(1), 111-119.? ? S Goto et al. Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary (...). Eur. Heart J. 2010, 31(21), 2601-2613.? ? M Kogushi et al. The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs. Eur. J. Pharmacol. 2011, 657(1-3), 131-137.? ? Y Kai et al. Prevention of the hypercontractile response to thrombin by proteinase-activated receptor-1 antagonist in subarachnoid hemorrhage. Stroke. 2007 Dec;38(12):3259-65. Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Signaling & Oncology A15 Thrombin (PAR) Potent and orally active PAR1 antagonist Chemical name 1-(3-tert-butyl-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethanone hydrobromide Parent CAS No. [751475-53-3] Order Size Unit Price Stock 2 mg €115.00 In Stock

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產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

E 5555 hydrobromide - Atopaxar hydrobromide

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2030

CAS [474550-69-1]

MF C29H38FN3O5.HBr
MW 608.54

Purity: 99%
Soluble in DMSO

E 5555 hydrobromide

Description

Potent and orally active thrombin receptor (or protease-activated receptor 1, PAR1) antagonist (IC50: 19 nM); E5555 showed potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 values of 64 and 31nM, respectively

LV Serebruany et al. The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease. Thromb. Haemost. 2009, 102(1), 111-119.?

S Goto et al. Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary (...). Eur. Heart J. 2010, 31(21), 2601-2613.?

M Kogushi et al. The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs. Eur. J. Pharmacol. 2011, 657(1-3), 131-137.?

Y Kai et al. Prevention of the hypercontractile response to thrombin by proteinase-activated receptor-1 antagonist in subarachnoid hemorrhage. Stroke. 2007 Dec;38(12):3259-65.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular Cell Signaling & Oncology A15 Thrombin (PAR)

Potent and orally active PAR1 antagonist

Chemical name

1-(3-tert-butyl-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethanone hydrobromide

Parent CAS No.

[751475-53-3]

產(chǎn)品資料

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