| 產(chǎn)品名稱 | Tacrolimus - FK 506 |
| 產(chǎn)品貨號 | Axon 2263 CAS [104987-11-3] MF C44H69NO12MW 804.02 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Potent Calcineurin inhibitor (calcium dependent serine/threonine protein phosphatase 2B). The mechanism of action of FK 506 (Tacrolimus) involves the formation of a molecular complex with the the immunophilin FKBP12 (IC50 value 3 nM), to reduce its peptidyl-prolyl isomerase activity. Tacrolimus potently inhibits T-cell activation-induced TNF-α, IL-1β, IL-2, IL-3, IL-4, and IL-6 production, but does not affect LPS-induced cytokine production and proliferation of normal cells, such as bone marrow cells. Immunosuppressant, neuroprotectant and anticonvulsant. References Certificates Categories Extra info A.W. Thomson et al. Mode of action of tacrolimus (FK506): molecular and cellular mechanisms. Ther. Drug Monit. 1995, 17, 584-591. ? G. Sierra-Paredes et al. Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants. CNS Neurosci. Ther. 2008, 14, 36-46. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Epigenetics Immunology Pain & Inflammation Immunomodulator NF-κB MAPK Calcineurin EC 3.1.3.16 Potent Calcineurin (Ca2+ dependent protein phosphatase 2B) inhibitor Chemical name (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-e Parent CAS No. [104987-11-3] Order Size Unit Price Stock 10 mg €100.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Tacrolimus - FK 506Axon 2263 CAS [104987-11-3] MF C44H69NO12
Description
Potent Calcineurin inhibitor (calcium dependent serine/threonine protein phosphatase 2B). The mechanism of action of FK 506 (Tacrolimus) involves the formation of a molecular complex with the the immunophilin FKBP12 (IC50 value 3 nM), to reduce its peptidyl-prolyl isomerase activity. Tacrolimus potently inhibits T-cell activation-induced TNF-α, IL-1β, IL-2, IL-3, IL-4, and IL-6 production, but does not affect LPS-induced cytokine production and proliferation of normal cells, such as bone marrow cells.
Immunosuppressant, neuroprotectant and anticonvulsant.
Potent Calcineurin (Ca2+ dependent protein phosphatase 2B) inhibitor
Chemical name(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-e Parent CAS No.[104987-11-3] |
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