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產(chǎn)品名稱

Selisistat - EX 527

產(chǎn)品貨號

Axon 1956 CAS [49843-98-3] MF C13H13ClN2OMW 248.71 Purity: 99% Soluble in DMSO Description Potent and selective deacetylase sirtin 1 (SIRT1) inhibitor; a useful tool for studying the relationship between SIRT1 and cell regulation; a potential agent the treatment of Huntington’s Disease (HD) References Certificates Categories Extra info AD Napper et al.? Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J. Med. Chem. 2005, 48, 8045-8054. ? JC Milne et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007, 450(7170), 712-716.? ? JM Solomon et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006, 26(1), 28-38.? ? Y Zhang et al. Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene. 2009, 28(3), 445-60.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Diabetes & Metabolism Epigenetics DNA-damage Response EC 3.5.1.98 SIRT Potent and selective SIRT1 inhibitor Chemical name 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide Parent CAS No. [49843-98-3] Order Size Unit Price Stock 10 mg €90.00 In Stock

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Selisistat - EX 527

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1956

CAS [49843-98-3]

MF C13H13ClN2O
MW 248.71

Purity: 99%
Soluble in DMSO

Selisistat

Description

Potent and selective deacetylase sirtin 1 (SIRT1) inhibitor; a useful tool for studying the relationship between SIRT1 and cell regulation; a potential agent the treatment of Huntington’s Disease (HD)

AD Napper et al.? Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J. Med. Chem. 2005, 48, 8045-8054.

JC Milne et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007, 450(7170), 712-716.?

JM Solomon et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006, 26(1), 28-38.?

Y Zhang et al. Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene. 2009, 28(3), 445-60.?

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology CNS Diabetes & Metabolism Epigenetics DNA-damage Response EC 3.5.1.98 SIRT

Potent and selective SIRT1 inhibitor

Chemical name

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

Parent CAS No.

[49843-98-3]

產(chǎn)品資料

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