| 產(chǎn)品名稱 | MLN 8237 - Alisertib |
| 產(chǎn)品貨號(hào) | Axon 2003 CAS [1028486-01-2] MF C27H20ClFN4O4MW 518.92 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description Second generation, orally bioavailable, potent and highly selective aurora A inhibitor References Certificates Categories Extra info DA Sloane et al. Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237. ACS Chem. Biol. 2010, 5(6), 563-576.? ? G G?rgün et al. A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma. Blood. 2010, 115(25), 5202-5213. ? M Tomita, N Mori. Aurora A selective inhibitor MLN8237 suppresses the growth and survival of HTLV-1-infected T-cells in vitro. Cancer Sci. 2010, 101(5), 1204-1211.?? ? MG Manfredi et al. Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays. Clin. Cancer Res. 2011, 17(24), 7614-7624.? Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Epigenetics EC 2.7.11.1 Aurora Second generation selective Aurora A inhibitor Chemical name 4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid Parent CAS No. [1028486-01-2] Order Size Unit Price Stock 5 mg €105.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
MLN 8237 - AlisertibAxon 2003 CAS [1028486-01-2] MF C27H20ClFN4O4
Description
Second generation, orally bioavailable, potent and highly selective aurora A inhibitor
Second generation selective Aurora A inhibitor
Chemical name4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid Parent CAS No.[1028486-01-2] |
| 產(chǎn)品資料 |
