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產(chǎn)品名稱

GSK 461364 analogue I

產(chǎn)品貨號

Axon 1625 CAS [929095-23-8] MF C26H27ClN4O3SMW 511.04 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Potent and selective Polo-like kinase (PLK) 1 inhibitor, more selective at PLK1 (IC50: 2 nM) over PLK3 (IC50: 630 nM) References Certificates Categories Extra info TR Rheault et al. Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophene carboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties. Bioorg. Med. Chem. Lett. 2010, 20(15), 4587-92. ? KA Emmitte et al. Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg. Med. Chem. Lett. 2009, 19(6), 1694-7. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology EC 2.7.11.21 PLK PLK1 Inhibitor Chemical name (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide Parent CAS No. [929095-23-8] Order Size Unit Price Stock 5 mg €110.00 In Stock

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現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

GSK 461364 analogue I

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1625

CAS [929095-23-8]

MF C26H27ClN4O3S
MW 511.04

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

GSK 461364 analogue I

Description

Potent and selective Polo-like kinase (PLK) 1 inhibitor, more selective at PLK1 (IC50: 2 nM) over PLK3 (IC50: 630 nM)

TR Rheault et al. Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophene carboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties. Bioorg. Med. Chem. Lett. 2010, 20(15), 4587-92.

KA Emmitte et al. Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg. Med. Chem. Lett. 2009, 19(6), 1694-7.

Certificate of Analysis
Material Safety Data Sheet

Cell Cycle Regulation Cell Signaling & Oncology EC 2.7.11.21 PLK

PLK1 Inhibitor

Chemical name

(R)-3-(1-(2-chlorophenyl)ethoxy)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide

Parent CAS No.

[929095-23-8]

產(chǎn)品資料

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