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產(chǎn)品名稱

BI 2536

產(chǎn)品貨號

Axon 1129 CAS [755038-02-9] MF C28H39N7O3MW 521.65 Purity: 99% Optical purity: >99% ee Soluble in DMSO Description Potent and selective polo-like kinase (PLK) 1 inhibitor. KEYWORDS:?BI 2536 | supplier | PLK1 inhibitor | BI2536 | BI-2536 | CAS [755038-02-9] | CHK2 | p53 | polo-like kinase | PLK-1 | malignancies | spindle assembly | mitotic arrest | apoptosis | anti-tumor | NSCLC

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

BI 2536

Based on 514 publications in PubMed 10 10 514

Axon 1129

CAS [755038-02-9]

MF C28H39N7O3
MW 521.65

Purity: 99%
Optical purity: >99% ee
Soluble in DMSO

BI 2536

Description

Potent and selective polo-like kinase (PLK) 1 inhibitor.

KEYWORDS:?BI 2536 | supplier | PLK1 inhibitor | BI2536 | BI-2536 | CAS [755038-02-9] | CHK2 | p53 | polo-like kinase | PLK-1 | malignancies | spindle assembly | mitotic arrest | apoptosis | anti-tumor | NSCLC

M?Steegmaier et al. BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo.?Curr Biol?2007, 17, 316-322.?

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P Lénárt et al.?The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.?Curr Biol?2007, 17(4), 304-15.?

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M Sebastian et al. The Efficacy and Safety of BI 2536, a Novel Plk-1 Inhibitor, in Patients with Stage IIIB/IV Non-small Cell Lung Cancer Who Had Relapsed after, or Failed, Chemotherapy. J. Thor. Oncol. 2010, 5(7), 1060-1067.?

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HJ Stewart et al. The polo-like kinase inhibitor BI 2536 exhibits potent activity against malignant plasma cells and represents a novel therapy in multiple myeloma. Exp. Hematol. 2011, 39(3), 330-338.?

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List of publications utilizing BI 2536 (Axon 1129) purchased from Axon Medchem

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology EC 2.7.11.21 PLK

PLK1 inhibitor

Chemical name

4-((R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-3-methoxy-N-(1-methyl-piperidin-4-yl)-benzamide

Parent CAS No.

[755038-02-9]

產(chǎn)品資料

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