<button id="eiezk"><video id="eiezk"></video></button>

產(chǎn)品名稱

Fingolimod - FTY 720

產(chǎn)品貨號

Axon 1485 CAS [162359-56-0] MF C19H34ClNO2MW 343.93 Purity: 98% Soluble in DMSO Description A sphingosine-1-phosphate receptor 1 modulator; immunosuppressant.?FTY720 also activates the p21-activated kinase-1 (PAK1). Therefore, it could be a candidate therapeutic drug for the treatment of heart failure and arrhythmias. References Certificates Categories Extra info EV Berdyshev et al. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. J. Biol. Chem. 2009, 284(9), 5467–77. ? KK Dev et al. Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis. Pharmacol. Ther. 2008, 117, 77-93. ? K Chiba et al. Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus. Cell Mol. Immunol. 2006, 3, 11-19.? ? U Kunzendorf et al. FTY720—the first compound of a new promising class of immunosuppressive drugs. Nephrol. Dial. Transplant. 2004, 19, 1677-1681. ? E.E. Egom et al. FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J. Mol. Cell. Cardiol. 2010, 48, 406-414. ? W. Liu et al. A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin. Circ Heart Fail. 2013 Jul;6(4):833-44. Certificate of Analysis Material Safety Data Sheet Angiogenesis Apoptosis Cardiovascular Immunology Miscellaneous Immunomodulator S1PR1 A13 PAK S1PR1 agonist; Immunosuppressant Chemical name 2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diol hydrochloride Parent CAS No. [162359-55-9] Order Size Unit Price Stock 10 mg €60.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Fingolimod - FTY 720

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 1485

CAS [162359-56-0]

MF C19H34ClNO2
MW 343.93

Purity: 98%
Soluble in DMSO

Fingolimod

Description

A sphingosine-1-phosphate receptor 1 modulator; immunosuppressant.?FTY720 also activates the p21-activated kinase-1 (PAK1). Therefore, it could be a candidate therapeutic drug for the treatment of heart failure and arrhythmias.

EV Berdyshev et al. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. J. Biol. Chem. 2009, 284(9), 5467–77.

KK Dev et al. Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis. Pharmacol. Ther. 2008, 117, 77-93.

K Chiba et al. Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus. Cell Mol. Immunol. 2006, 3, 11-19.?

U Kunzendorf et al. FTY720—the first compound of a new promising class of immunosuppressive drugs. Nephrol. Dial. Transplant. 2004, 19, 1677-1681.

E.E. Egom et al. FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J. Mol. Cell. Cardiol. 2010, 48, 406-414.

W. Liu et al. A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin. Circ Heart Fail. 2013 Jul;6(4):833-44.

Certificate of Analysis
Material Safety Data Sheet

Angiogenesis Apoptosis Cardiovascular Immunology Miscellaneous Immunomodulator S1PR1 A13 PAK

S1PR1 agonist; Immunosuppressant

Chemical name

2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diol hydrochloride

Parent CAS No.

[162359-55-9]

產(chǎn)品資料

<button id="eiezk"><video id="eiezk"></video></button>