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產(chǎn)品名稱

NSC 59984

產(chǎn)品貨號

Axon 2564 CAS [803647-40-7] MF C12H15N3O4MW 265.27 Purity: 100% Soluble in 0.1N HCl(aq) and DMSO Description Activator of p53 that restores wild-type p53 signaling via p73 activation, specifically in mutant p53-expressing colorectal cancer cells, inducing cell death in colorectal cancer cells with minimal genotoxicity and without evident toxicity toward normal cells. Remarkebly, NSC 59984 induces degradation of several p53 mutants through MDM2-mediated ubiquitination. KEYWORDS: NSC 59984 | supplier | p53 activator | NSC59984 | NSC-59984 | CAS [803647-40-7] | DNA-RNA | p53 | Activator | Transcription Factor | MDM2 | p73 | HDM | colorectal | cancer | ubiquitination | apoptosis

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

NSC 59984

Based on 15 reference(s) in Google Scholar 9 10 15

Axon 2564

CAS [803647-40-7]

MF C12H15N3O4
MW 265.27

Purity: 100%
Soluble in 0.1N HCl(aq) and DMSO

NSC 59984

Description

Activator of p53 that restores wild-type p53 signaling via p73 activation, specifically in mutant p53-expressing colorectal cancer cells, inducing cell death in colorectal cancer cells with minimal genotoxicity and without evident toxicity toward normal cells. Remarkebly, NSC 59984 induces degradation of several p53 mutants through MDM2-mediated ubiquitination.

KEYWORDS: NSC 59984 | supplier | p53 activator | NSC59984 | NSC-59984 | CAS [803647-40-7] | DNA-RNA | p53 | Activator | Transcription Factor | MDM2 | p73 | HDM | colorectal | cancer | ubiquitination | apoptosis

S Zhang et al. Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53. Cancer Res. 2015 Sep 15;75(18):3842-52.

M Ferraiuolo et al. Oncogenic Intra-p53 Family Member Interactions in Human Cancers. Front Oncol. 2016 Mar 31;6:77.

B Hong et al. Targeting tumor suppressor p53 for cancer therapy: strategies, challenges and opportunities. Curr Drug Targets. 2014 Jan;15(1):80-9.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology p53 Transcription Factors DNA-damage Response Ubiquitin TF class 4.3.1

Activator of p53 that restores WT p53 signaling via p73 activation

Chemical name

(E)-1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one

Parent CAS No.

[803647-40-7]

產(chǎn)品資料

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