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產(chǎn)品名稱

SCH 529074

產(chǎn)品貨號(hào)

Axon 2244 CAS [922150-11-6] MF C31H36Cl2N6MW 563.56 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Small molecule activator of mutant p53 which binds p53 DNA binding domain (DBD; Kd value 1-2 μM). SCH 529074 restores growth-suppressive function to mutant p53 (R273H and the structural mutant R249S) by acting as a chaperone and interrupts HDM2-mediated ubiquitination of wild type p53. References Certificates Categories Extra info M. Demma et al. SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination (...). J. Biol. Chem. 2010, 285, 10198-10212. ? F. Essmann et al. Translational approaches targeting the p53 pathway for anti-cancer therapy. Br. J. Pharmacol. 2012, 165, 328-344. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology p53 Transcription Factors DNA-damage Response Ubiquitin TF class 4.3.1 Small molecule activator of mutant p53. Chemical name N1-(2-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine Parent CAS No. [922150-11-6] Order Size Unit Price Stock 5 mg €100.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

SCH 529074

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2244

CAS [922150-11-6]

MF C31H36Cl2N6
MW 563.56

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

SCH 529074

Description

Small molecule activator of mutant p53 which binds p53 DNA binding domain (DBD; Kd value 1-2 μM). SCH 529074 restores growth-suppressive function to mutant p53 (R273H and the structural mutant R249S) by acting as a chaperone and interrupts HDM2-mediated ubiquitination of wild type p53.

M. Demma et al. SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination (...). J. Biol. Chem. 2010, 285, 10198-10212.

F. Essmann et al. Translational approaches targeting the p53 pathway for anti-cancer therapy. Br. J. Pharmacol. 2012, 165, 328-344.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology p53 Transcription Factors DNA-damage Response Ubiquitin TF class 4.3.1

Small molecule activator of mutant p53.

Chemical name

N1-(2-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine

Parent CAS No.

[922150-11-6]

產(chǎn)品資料

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