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產(chǎn)品名稱

MLN 4924 - Pevonedistat

產(chǎn)品貨號(hào)

Axon 2038 CAS [905579-51-3] MF C21H25N5O4SMW 443.52 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description First-in-class inhibitor of NEDD8 Activating Enzyme (NAE) with potent antitumor activity in animal models; cell permeable; MLN4924 inactivates Cullin-RING E3 ubiquitin Ligases (CRLs) by blocking cullin neddylation References Certificates Categories Extra info TA Soucy et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 2009, 458, 732-736.?? ? TA Soucy et al. Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of Cancer. Clin. Cancer Res. 2009, 15, 3912.?? ? Y Zhao et al. Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death and Disease 2012, 3, e386.? ? JL Toth et al. A Gatekeeper Residue for NEDD8-Activating Enzyme Inhibition by MLN4924. Cell Reports, 2012, 1(4), 309-316.? Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology CNS Ubiquitin EC 6.2.1 Ubiquitin Ligase (E1) Inhibitor of NEDD8 Activating Enzyme (NAE) Chemical name ((1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate Parent CAS No. [905579-51-3] Order Size Unit Price Stock 1 mg €75.00 In Stock

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現(xiàn)貨詢價(jià)，電話：010-67529703

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產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

MLN 4924 - Pevonedistat

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2038

CAS [905579-51-3]

MF C21H25N5O4S
MW 443.52

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

MLN 4924

Description

First-in-class inhibitor of NEDD8 Activating Enzyme (NAE) with potent antitumor activity in animal models; cell permeable; MLN4924 inactivates Cullin-RING E3 ubiquitin Ligases (CRLs) by blocking cullin neddylation

TA Soucy et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 2009, 458, 732-736.??

TA Soucy et al. Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of Cancer. Clin. Cancer Res. 2009, 15, 3912.??

Y Zhao et al. Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death and Disease 2012, 3, e386.?

JL Toth et al. A Gatekeeper Residue for NEDD8-Activating Enzyme Inhibition by MLN4924. Cell Reports, 2012, 1(4), 309-316.?

Certificate of Analysis
Material Safety Data Sheet

Cell Cycle Regulation Cell Signaling & Oncology CNS Ubiquitin EC 6.2.1 Ubiquitin Ligase (E1)

Inhibitor of NEDD8 Activating Enzyme (NAE)

Chemical name

((1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate

Parent CAS No.

[905579-51-3]

產(chǎn)品資料

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