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產(chǎn)品名稱

Nutlin-3

產(chǎn)品貨號

Axon 1585 CAS [548472-68-0] MF C30H30Cl2N4O4MW 581.49 Purity: 99% Soluble in DMSO and Ethanol Description MDM2 antagonist, which binds MDM2 in the p53-binding pocket and activates the p53 pathway in cancer cells, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts in nude mice. Note: Its two enantiomers, more active (-)-enantiomer Nutlin-3a (Axon 1880) and less active (+)-enantiomer Nutlin-3b (Axon 1881), are also available. References Certificates Categories Extra info LT Vassilev et al. In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2. Science 2004, 303, 844-848.? ? S Shangary and S Wang. Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy. Ann. Rev. Pharmacol. Toxicol. 2008, 49: 223–241.? Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Transcription Factors p53-Tumor Suppression Ubiquitin EC 6.3.2.19 HDM-MDM MDM2 inhibitor (p53 specific) Chemical name 4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one Parent CAS No. [548472-68-0] Order Size Unit Price Stock 5 mg €95.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Nutlin-3

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1585

CAS [548472-68-0]

MF C30H30Cl2N4O4
MW 581.49

Purity: 99%
Soluble in DMSO and Ethanol

Nutlin-3

Description

MDM2 antagonist, which binds MDM2 in the p53-binding pocket and activates the p53 pathway in cancer cells, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts in nude mice.

Note: Its two enantiomers, more active (-)-enantiomer Nutlin-3a (Axon 1880) and less active (+)-enantiomer Nutlin-3b (Axon 1881), are also available.

LT Vassilev et al. In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2. Science 2004, 303, 844-848.?

S Shangary and S Wang. Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy. Ann. Rev. Pharmacol. Toxicol. 2008, 49: 223–241.?

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Transcription Factors p53-Tumor Suppression Ubiquitin EC 6.3.2.19 HDM-MDM

MDM2 inhibitor (p53 specific)

Chemical name

4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

Parent CAS No.

[548472-68-0]

產(chǎn)品資料

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