| 產(chǎn)品名稱 | JTP 1048196 |
| 產(chǎn)品貨號 | Axon 2947 CAS [55377-56-5] MF C17H14O4MW 282.29 Purity: 99% Soluble in DMSO Recently added |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
JTP 1048196Axon 2947 CAS [55377-56-5] MF C17H14O4
Recently added
DescriptionJTP 1048196 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 value of 16.1 μM for inhibition of linear polyubiquitination activity by the HOIL-1L/HOIP complex. The lactone structure of JTP 1048196 was transformed to the reactive α,β-unsaturated carbonyl moiety JTP 0819958 (Axon 2939) which reacts with the cysteine residue of LUBAC, leading to its covalent inhibition in vitro and cellular levels. KEYWORDS: JTP 1048196 | supplier | LUBAC inhibitor | JTP1048196 | JTP-1048196 | CAS [55377-56-5] | NF-κB Pathway | Ubiquitin Ligase (E3; LUBAC) | Inhibitor | Enzymes | HOIL-1L | HOIP | SHARPIN
Prodrug of JTP 0819958; LUBAC inhibitor
Chemical name3-(2-(2-Methoxyphenyl)-2-oxoethyl)isobenzofuran-1(3H)-one Parent CAS No.[55377-56-5] |
| 產(chǎn)品資料 |
