| 產(chǎn)品名稱 | Spautin 1 - MBCQ derivative C43 |
| 產(chǎn)品貨號 | Axon 2512 CAS [1262888-28-7] MF C15H11F2N3MW 271.26 Purity: 99% Soluble in DMSO Description Inhibitor of USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes, thereby promoting the degradation of Vps34 PI3 kinase complexes. Beclin1 is a tumor suppressor and regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53. Moreover, Spautin 1 inhibits autophagy which enhances imatinib-induced apoptosis in chronic myeloid leukemia. The pro-apoptotic activity of Spautin-1 was also associated with activation of GSK-3β, an important downstream effector of PI3K/AKT. KEYWORDS: Spautin 1 | supplier | USP10-USP13 inhibitor | MBCQ derivative C43 | Spautin1 | CAS [1262888-28-7] | Ubiquitin | Deubiquitinase | Beclin 1 | Vps34 | PI3K | Akt | p53 | apoptosis | autophagy | GSK-3β |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Spautin 1 - MBCQ derivative C43Axon 2512 CAS [1262888-28-7] MF C15H11F2N3
DescriptionInhibitor of USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes, thereby promoting the degradation of Vps34 PI3 kinase complexes. Beclin1 is a tumor suppressor and regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53. Moreover, Spautin 1 inhibits autophagy which enhances imatinib-induced apoptosis in chronic myeloid leukemia. The pro-apoptotic activity of Spautin-1 was also associated with activation of GSK-3β, an important downstream effector of PI3K/AKT. KEYWORDS: Spautin 1 | supplier | USP10-USP13 inhibitor | MBCQ derivative C43 | Spautin1 | CAS [1262888-28-7] | Ubiquitin | Deubiquitinase | Beclin 1 | Vps34 | PI3K | Akt | p53 | apoptosis | autophagy | GSK-3β
Inhibitor of USP10 and USP13 and Beclin1 related autophagy
Chemical name6-fluoro-N-(4-fluorobenzyl)quinazolin-4-amine Parent CAS No.[1262888-28-7] |
| 產(chǎn)品資料 |
