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產(chǎn)品名稱

KDU691

產(chǎn)品貨號(hào)

Axon 2845 CAS [1513879-19-0] MF C22H18ClN5O2MW 419.86 Purity: 99% Soluble in DMSO Description KDU691 is a plasmodium PI4K inhibitor (IC50 values of 0.18 μM and 0.061 μM against hypnozoite forms and liver schizontsm, respectively) which selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites. Moreover, KDU691 was fully protective when administered in vivo as causal prophylactic and radical-cure agents for Plasmodium cynomolgi sporozoite-infected rhesus macaques. KEYWORDS: KDU691 | supplier | PI4K inhibitor | KDU-691 | KDU 691 | CAS [1513879-19-0] | Phosphatidylinositol | PI4K | Inhibitor | Enzymes | Plasmodium

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

KDU691

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 2845

CAS [1513879-19-0]

MF C22H18ClN5O2
MW 419.86

Purity: 99%
Soluble in DMSO

KDU691

Description

KDU691 is a plasmodium PI4K inhibitor (IC50 values of 0.18 μM and 0.061 μM against hypnozoite forms and liver schizontsm, respectively) which selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites. Moreover, KDU691 was fully protective when administered in vivo as causal prophylactic and radical-cure agents for Plasmodium cynomolgi sporozoite-infected rhesus macaques.

AM Zeeman et al. PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2858-63.

L Dembele et al. The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites. Sci Rep. 2017 May 24;7(1):2325.

Certificate of Analysis
Material Safety Data Sheet

Miscellaneous PI3K-Akt-mTOR PI4K

PI4K inhibitor

Chemical name

N-(4-Chlorophenyl)-N-methyl-3-(4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide

Parent CAS No.

[1513879-19-0]

產(chǎn)品資料

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