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產(chǎn)品名稱

VE 821

產(chǎn)品貨號(hào)

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

VE 821

Based on 401 reference(s) in Google Scholar 10 10 401

Axon 1893

CAS [1232410-49-9]

MF C18H16N4O3S
MW 368.41

Purity: 99%
Soluble in DMSO

VE 821

Description

Potent and selective inhibitor of the DNA damage response (DDR) kinase ATR. which sensitises tumour cells to DNA damage induced by radiation or chemotoxic drugs, by disrupting the DNA damage checkpoint and inhibiting DNA repair.

PM Reaper et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat. Chem. Biol. 2011, 7(7), 428-430.

IM Pires et al. Targeting radiation-resistant hypoxic tumour cells through ATR inhibition. Br. J. Cancer. 2012, 107(2), 291-299.

R Prevo et al. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biol. Ther. 2012, 13, 1072-1081

List of publications using VE 821 (Axon 1893) purchased from Axon Medchem

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology ATR p53-Tumor Suppression PI3K-Akt-mTOR DNA-damage Response EC 2.7.11.1

Inhibitor of the DNA damage response kinase ATR

Chemical name

3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide

Parent CAS No.

[1232410-49-9]

產(chǎn)品資料

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