| 產(chǎn)品名稱 | NVP-BBD130 - BBD 130 |
| 產(chǎn)品貨號 | Axon 1520 CAS [853910-61-9] MF C28H21N5OMW 443.50 Purity: 99% Moderately soluble in DMSO Description Orally potent and selective dual PI3K/mTOR inhibitor; IC50 values to be 72, 2336, 201 and 382 nM for PI3K p110 α, β, δ and γ isoforms, respectively; inhibition of PI3K/mTOR pathway like NVP-BEZ235, BBD130 efficiently attenuates growth and proliferation of melanoma primary tumors and metastasis References Certificates Categories Extra info R Marone et al. Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors. Mol. Cancer Res. 2009, 7(4), 601-613.? ? F Stauffer et al. Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway. Bioorg. Med. Chem. Lett. 2008, 18, 1027-1030. ? SM Maria, P Furet and F Stauffer. Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway. Future Med. Chem. 2009, 1(1), 137-155. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology PI3K PI3K-Akt-mTOR EC 2.7.1.153 Dual PI3K and mTOR kinase inhibitor Chemical name 2-Methyl-2-[4-(3-methyl-2-oxo-8-pyridin-3ylethynyl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile Parent CAS No. [853910-61-9] Order Size Unit Price Stock 5 mg €125.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
NVP-BBD130 - BBD 130Axon 1520 CAS [853910-61-9] MF C28H21N5O
Description
Orally potent and selective dual PI3K/mTOR inhibitor; IC50 values to be 72, 2336, 201 and 382 nM for PI3K p110 α, β, δ and γ isoforms, respectively; inhibition of PI3K/mTOR pathway like NVP-BEZ235, BBD130 efficiently attenuates growth and proliferation of melanoma primary tumors and metastasis
Dual PI3K and mTOR kinase inhibitor
Chemical name2-Methyl-2-[4-(3-methyl-2-oxo-8-pyridin-3ylethynyl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile Parent CAS No.[853910-61-9] |
| 產(chǎn)品資料 |
