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產(chǎn)品名稱

AS 252424

產(chǎn)品貨號(hào)

Axon 1424 CAS [900515-16-4] MF C14H8FNO4SMW 305.28 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description Potent and selective PI3K p110γ inhibitor; IC50 values for inhibition of human recombinant PI3Kγ, α, β, and δ are 30, 940, 20,000, and 20,000 nM respectively.?A water-soluble bispotassium salt form of AS 252424 is available as well (Axon 1436). References Certificates Categories Extra info V Pomel et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J. Med. Chem. 2006, 49, 3857-3871. ? T Rückle et al. PI3Kγ inhibition: Towards an 'aspirin of the 21st century'?. Nature Reviews Drug Discovery 2006, 5, 903-918. ? BT Hennessy?et al. Exploiting the PI3K/AKT pathway for cancer drug discovery.Nat. Rev. Drug Discov. 2005,4,?988-1004. ? AM Condliffe et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 2005, 106, 1432-1440. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology PI3K PI3K-Akt-mTOR EC 2.7.1.153 PI3K inhibitor (p110-γ specific) Chemical name 5-[1-[5-(4-Fluoro-2-hydroxy-phenyl)-furan-2-yl]-meth-(Z)-ylidene]-thiazolidine-2,4-dione Parent CAS No. [900515-16-4] Order Size Unit Price Stock 5 mg €85.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

AS 252424

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 1424

CAS [900515-16-4]

MF C14H8FNO4S
MW 305.28

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

AS 252424

Description

Potent and selective PI3K p110γ inhibitor; IC50 values for inhibition of human recombinant PI3Kγ, α, β, and δ are 30, 940, 20,000, and 20,000 nM respectively.?A water-soluble bispotassium salt form of AS 252424 is available as well (Axon 1436).

V Pomel et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J. Med. Chem. 2006, 49, 3857-3871.

T Rückle et al. PI3Kγ inhibition: Towards an 'aspirin of the 21st century'?. Nature Reviews Drug Discovery 2006, 5, 903-918.

BT Hennessy?et al. Exploiting the PI3K/AKT pathway for cancer drug discovery.Nat. Rev. Drug Discov. 2005,4,?988-1004.

AM Condliffe et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 2005, 106, 1432-1440.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology PI3K PI3K-Akt-mTOR EC 2.7.1.153

PI3K inhibitor (p110-γ specific)

Chemical name

5-[1-[5-(4-Fluoro-2-hydroxy-phenyl)-furan-2-yl]-meth-(Z)-ylidene]-thiazolidine-2,4-dione

Parent CAS No.

[900515-16-4]

產(chǎn)品資料

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