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產(chǎn)品名稱

PIK 90

產(chǎn)品貨號

Axon 1362 CAS [677338-12-4] MF C18H17N5O3MW 351.36 Purity: 99% Moderately soluble in DMSO with 0.1N HCl(aq) Description Potent and cell permeable PI3K inhibitor, with IC50 values (nM) of 11, 350, 18, and 58 for p110 α, β, γ and δ isoforms, low mTOR activity. KEYWORDS:?PIK 90 | supplier | PI3K p110α inhibitor | PIK90 | PIK-90 | CAS [677338-12-4] - [677338-13-5]

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

PIK 90

Based on 197 reference(s) in Google Scholar 10 10 197

Axon 1362

CAS [677338-12-4]

MF C18H17N5O3
MW 351.36

Purity: 99%
Moderately soluble in DMSO with 0.1N HCl(aq)

PIK 90

Description

Potent and cell permeable PI3K inhibitor, with IC50 values (nM) of 11, 350, 18, and 58 for p110 α, β, γ and δ isoforms, low mTOR activity.

KEYWORDS:?PIK 90 | supplier | PI3K p110α inhibitor | PIK90 | PIK-90 | CAS [677338-12-4] - [677338-13-5]?| Phosphatidylinositol | p110-alpha | cell permeable | mTOR

JS Chen et al. Characterization of structurally distinct, isoform-selective phosphoinositide 3′-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Mol. Cancer Ther. 2008, 7, 841-850.

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ZA Knight et al. A Pharmacological Map of the PI3-K Family Defines a Role for p110α?in Insulin Signaling. Cell 2006, 125, 733–747.

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C Chaussade et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.?Biochem J.?2007,?404(3), 449–458.

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S Kim et al.?Insulin-like growth factor-1 regulates platelet activation through PI3-Kα?isoform.?Blood, 2007, 110(13), 4206-4213.

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List of publications using PIK 90 (Axon 1362) purchased from Axon Medchem

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology PI3K PI3K-Akt-mTOR EC 2.7.1.153

PI3K inhibitor (p110-α specific)

Chemical name

N-(7,8-Dimethoxy-2,3-dihydro-imidazo[1,2-c]quinazolin-5-yl)-nicotinamide

Parent CAS No.

[677338-12-4]

產(chǎn)品資料

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