| 產(chǎn)品名稱 | Brexpiprazole dihydrochloride - OPC 34712 dihydrochloride |
| 產(chǎn)品貨號 | Axon 2335 CAS [913612-38-1] MF C25H27N3O2S.2HClMW 506.49 Purity: 98% Soluble in DMSO Description Drug candidate in clinical development for psychiatric disorders with high affinity for h5-HT1A (partial agonist), h5-HT2A (antagonist), hD2L (partial agonist), hα1B (antagonist) and hα2C-adrenergic (antagonist) receptors (Ki values <1 nM). Brexpiprazole also shows substantial affinity (Ki <5 nM) for hD3, h5-HT2B, h5-HT7, hα1A and hα1D adrenergic receptors, and moderate affinity for hH1 (Ki =19 nM). References Certificates Categories Extra info K. Maeda et al. Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator. J Pharmacol Exp Ther. 2014 Sep;350(3):589-604. ? K. Maeda et al. Brexpiprazole II: antipsychotic-like and procognitive effects of a novel serotonin-dopamine activity modulator. J Pharmacol Exp Ther. 2014 Sep;350(3):605-14. ? N. Yoshimi et al. Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors. Pharmacol Biochem Behav. 2014 Sep;124:245-9. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS D2 D3 5-HT1A 5-HT7 5-HT2A Adrenoceptor α2 Adrenoceptor α1 A17 A19 Drug candidate with high affinity for 5-HT1A, 5-HT2A, D2L, α1B, and α2C-adrenergic receptors Chemical name 7-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one dihydrochloride Parent CAS No. [913611-97-9] Order Size Unit Price Stock 5 mg €135.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
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| 產(chǎn)品詳情 |
Brexpiprazole dihydrochloride - OPC 34712 dihydrochlorideAxon 2335 CAS [913612-38-1] MF C25H27N3O2S.2HCl
Description
Drug candidate in clinical development for psychiatric disorders with high affinity for h5-HT1A (partial agonist), h5-HT2A (antagonist), hD2L (partial agonist), hα1B (antagonist) and hα2C-adrenergic (antagonist) receptors (Ki values <1 nM). Brexpiprazole also shows substantial affinity (Ki <5 nM) for hD3, h5-HT2B, h5-HT7, hα1A and hα1D adrenergic receptors, and moderate affinity for hH1 (Ki =19 nM).
Drug candidate with high affinity for 5-HT1A, 5-HT2A, D2L, α1B, and α2C-adrenergic receptors
Chemical name7-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one dihydrochloride Parent CAS No.[913611-97-9] |
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