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產(chǎn)品名稱(chēng)

GMC 1-116

產(chǎn)品貨號(hào)

Axon 1151 CAS [63687-94-5] MF C18H20N4OMW 308.38 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Analogue and metabolite of clozapine (Axon 1146); devoid of DA and α1 affinities, with weak 5-HT2 affinities but high M1 affinity (IC50=27 nM). Another analogue and metabolite of cloazapine, with 2-Hydroxy moiety,

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

GMC 1-116

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 1151

CAS [63687-94-5]

MF C18H20N4O
MW 308.38

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

GMC 1-116

Description

Analogue and metabolite of clozapine (Axon 1146); devoid of DA and α1 affinities, with weak 5-HT2 affinities but high M1 affinity (IC50=27 nM).

Another analogue and metabolite of cloazapine, with 2-Hydroxy moiety,?GMC1-165?(Axon 1152), is also available.

Liao, Y. et al. Synthesis and pharmacological evaluation of triflate-substituted analogues of Clozapine: Identification of a novel atypical neuroleptic.?J. Med. Chem. 1997,?40, 4146-4153.

Y. Liao et al. New sulfonyloxy piperazinyldibenzazapines as potential atypical antipsychotics: chemistry and pharmacological evaluation.?J. Med. Chem. 1999,42, 2235-2244.

Certificate of Analysis
Material Safety Data Sheet

CNS Non Selective (Serotonin; Dopamine) D (Non Selective) 5-HT (Non Selective) A17

Clozapine analogue

Chemical name

11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-8-ol

Parent CAS No.

[63687-94-5]

產(chǎn)品資料

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