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產(chǎn)品名稱

PF 04691502

產(chǎn)品貨號

Axon 1855 CAS [1013101-36-4] MF C22H27N5O4MW 425.48 Purity: 99% Soluble in DMSO Description Potent, selective, oral and ATP-competitive inhibitor of class I PI3K (Ki: 1-2 nM) and mTOR kinases (Ki: 16 nM); it inhibits PI3K/mTOR signaling and induces cell cycle arrest in cancer cells References Certificates Categories Extra info J Yuan et al. PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. Mol. Cancer Ther. 2011, 10, 2189. ? H Cheng et al. Discovery of the highly potent PI3K/mTOR dual inhibitor PF-04691502 through structure based drug design. Med. Chem. Commun. 2010, 1, 139-144.? Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology PI3K mTOR PI3K-Akt-mTOR EC 2.7.11.1 Pfizer Licensed Products PI3K and mTOR tyrosine kinase inhibitor Chemical name 2-amino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [1013101-36-4] Order Size Unit Price Stock 5 mg €90.00 In Stock

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

PF 04691502

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1855

CAS [1013101-36-4]

MF C22H27N5O4
MW 425.48

Purity: 99%
Soluble in DMSO

PF 04691502

Description

Potent, selective, oral and ATP-competitive inhibitor of class I PI3K (Ki: 1-2 nM) and mTOR kinases (Ki: 16 nM); it inhibits PI3K/mTOR signaling and induces cell cycle arrest in cancer cells

J Yuan et al. PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. Mol. Cancer Ther. 2011, 10, 2189.

H Cheng et al. Discovery of the highly potent PI3K/mTOR dual inhibitor PF-04691502 through structure based drug design. Med. Chem. Commun. 2010, 1, 139-144.?

Certificate of Analysis
Material Safety Data Sheet

Cell Cycle Regulation Cell Signaling & Oncology PI3K mTOR PI3K-Akt-mTOR EC 2.7.11.1 Pfizer Licensed Products

PI3K and mTOR tyrosine kinase inhibitor

Chemical name

2-amino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Source information

Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.

Parent CAS No.

[1013101-36-4]

產(chǎn)品資料

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