| 產(chǎn)品名稱 | SB 332235 |
| 產(chǎn)品貨號 | Axon 2593 CAS [276702-15-9] MF C13H10Cl3N3O4SMW 410.66 Purity: 98% Soluble in 0.1N NaOH(aq) and DMSO Description Selective nonpeptide CXCR2 antagonist (IC50 values 9.3 nM and 9.6 μM for CXCR2 and CXCR1, respectively) exhibiting significant anti-inflammatory effects in acute and chronic models of arthritis in the rabbit. SB-332235 significantly reduced levels of proinflammatory mediators in the synovial fluid, including TNF-α, IL-8, PGE2, LTB4, and LTC4. SB-332235 was also found to abolish the GRO/CINC-1 mediated inhibition of C2-ceramide-induced cytochrome-c release from mitochondria. KEYWORDS:?SB 332235 | supplier | CXCR2 antagonist | SB332235 | SB-332235 | CAS [276702-15-9] | Chemokine | GPCR | anti-inflammatory | arthritis | ?TNF-α | IL-8 | interleukin-8 | PGE2 | prostaglandin | LTB4 | LTC4 | Alzheimer's | apoptosis |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
SB 332235Axon 2593 CAS [276702-15-9] MF C13H10Cl3N3O4S
DescriptionSelective nonpeptide CXCR2 antagonist (IC50 values 9.3 nM and 9.6 μM for CXCR2 and CXCR1, respectively) exhibiting significant anti-inflammatory effects in acute and chronic models of arthritis in the rabbit. SB-332235 significantly reduced levels of proinflammatory mediators in the synovial fluid, including TNF-α, IL-8, PGE2, LTB4, and LTC4. SB-332235 was also found to abolish the GRO/CINC-1 mediated inhibition of C2-ceramide-induced cytochrome-c release from mitochondria. KEYWORDS:?SB 332235 | supplier | CXCR2 antagonist | SB332235 | SB-332235 | CAS [276702-15-9] | Chemokine | GPCR | anti-inflammatory | arthritis | ?TNF-α | IL-8 | interleukin-8 | PGE2 | prostaglandin | LTB4 | LTC4 | Alzheimer's | apoptosis
Nonpeptide CXCR2 antagonist exhibiting significant anti-inflammatory effects
Chemical name6-chloro-3-(3-(2,3-dichlorophenyl)ureido)-2-hydroxybenzenesulfonamide Parent CAS No.[276702-15-9] |
| 產(chǎn)品資料 |
